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TrialMind vs Rayyan vs Nested Knowledge

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TrialMind vs Rayyan vs Nested Knowledge: systematic review tools compared, from each company’s public pages, checked 2026-10-21
TrialMindKeiji AIAI agents for HEOR reviewsRayyanAI-assisted literature review platformNested KnowledgeLiving review and meta-analysis software
Best forHEOR reviews that must become HTA dossiers, with a reason per decisionA free start and low seat prices, with AI screening on institutional plansLiving reviews with built-in network meta-analysis and visual outputs
Review
AI screeningYes: Every abstract scored against criteriaYes: ResearchPilot AI Reviewer1Yes: Robot Screener as second reviewer2
AI data extractionYes: Tables linked to source papersYes: Auto Extraction highlights source text1Partly: Smart Tags extract PICO from abstracts3
Reason for every exclusionYes: Recorded reason for every decisionYes: AI decisions with reasoning notes1No: Robot Screener gives no exclusion reasons2
PRISMA flow diagramYes: PRISMA-reported outputYes: Generated automatically4Yes: Generated from AutoLit screening5
Synthesis and HTA
Indirect comparison or NMAYes: Bucher and other ITCs, documentedNot stated publicly4Yes: NMA with forest plots, SUCRA6
HTA dossier formatsYes: NICE, G-BA, CADTH, HAS, PBACNot stated publicly4Partly: Supports HTA; no dossier formats stated7
Access
Deployment and securityCloud or your environment; SOC 2, ISO 27001SOC 2, ISO 27001, HIPAA, GDPR4Browser-based; certifications not stated8
PricingQuote from Keiji AIFree plan; seats from $4.99/month9From $295 per user per month10

From each company’s public pages, checked 2026-10-21. A dash means the company does not say.

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Sources · checked 2026-10-21

Product details come from each company’s public pages. Spotted something out of date? Tell us and we will correct it.

  1. Rayyan: www.rayyan.ai/researchpilot
  2. Nested Knowledge: about.nested-knowledge.com/docs/robot-screener/
  3. Nested Knowledge: about.nested-knowledge.com/docs/core-smart-tags/
  4. Rayyan: www.rayyan.ai/
  5. Nested Knowledge: about.nested-knowledge.com/features/
  6. Nested Knowledge: about.nested-knowledge.com/docs/explore-nma/
  7. Nested Knowledge: about.nested-knowledge.com/health-economics-and-outcomes-research/
  8. Nested Knowledge: about.nested-knowledge.com/docs/supported-platforms/
  9. Rayyan: www.rayyan.ai/pricing
  10. Nested Knowledge: about.nested-knowledge.com/pricing/